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Ritonavir or lopinavir/ritonavir greatly boost plasma concentrations of oxycodone in healthful human volunteers resulting from inhibition of CYP3A4 and CYP2D6.[fifty eight] Rifampicin enormously reduces plasma concentrations of oxycodone on account of strong induction of CYP3A4.The Lively component of the approved drug products is what tends to mak